Results: In the fully adjusted model, significant positive associations between P_CARB and CVD risk were observed in the pooled analysis, showing that the HRs (95% CIs) for CVD across increasing quartiles of P_CARB were 1.00 (reference), 1.16 (0.94-1.44), 1.25 (0.96-1.63), and 1.48 (1.08-2.03). The restricted cubic spline regression analysis confirmed a linear dose-response relationship between P_CARB and CVD risk in both cohort studies, with all p-values for nonlinearity >0.05.

Conclusion: Our findings suggest that a carbohydrate-based diet high in proportion to total energy intake may increase the risk of CVD among middle-aged Korean adults, underscoring the importance of balanced macronutrient distribution. However, more research is needed to evaluate the sources and quality of carbohydrates in relation to CVD risk in this population.

Full Paper: https://doi.org/10.1016/j.clnu.2023.06.013

  • jet@hackertalks.comOPMEnglish
    1·
    2 months ago

    This paper is based on analysis of two epidemiological papers, which makes this just refined epidemiology as well. It is hypothesis generating, and only demonstrates associations and cannot inform on causation. Only reports weak hazard ratios, and does not inform on absolute risk. The paper makes inference s

    May can also mean May Not.

    That said, it’s interesting to see a dose dependent increase in CVD risk (not mortality). The lowest carbohydrate quintile in this study was 60% carbohydrates! So this isn’t speaking to keto, low-carb or anything like that. This is just showing a dose dependent response to CVD risk going from 60%,70%,74%,80% carbohydrate % of daily intake.