Any drug interaction that I should be worried about?
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The effects potentiate each other, so you will be tripping much harder.
If you tolerate weed well otherwise, it can work out well. If you’re prone to paranoia, anxiety, and similar effects, this combination can great increase them.
Now that I’ve experimented with the combo, I would say that cannabis interferes with the profound impartiality of ayahuasca. I enjoy ayahuasca more without cannabis.