Source.
Visa & Master Card blocked Payments for steam games.
Alt text: Fancy guy with Visa/Mastercard logo on his head in suit says: I do not think people should be allowed to buy these type of games. itch.io and steam reply: nobody is talking to you. Just process the payment, payment processor.
There are select places where it’s usable, but generally speaking most merchants don’t accept it. You can sometimes buy giftcards or something like that with crypto and just use the giftcard to pay, but honestly that’s kind of a pain. Also I’m only talking about Bitcoin and Monero. Most of the other currencies I probably wouldn’t bother using.