The biggest issue you will find is getting gtk and qt apps to look, feel and integrate together. There is nothing wrong with mixing and matching, it can just get a bit complicated. Lots of people don’t even use a de, and just build their own gui with a compositor or window manager, plus all the tools and apps they want to include to make it functional. I haven’t used a de in over a decade on my main desktop.

For me I really want to move over to a Linux phone in the next few years. My current phone doesn’t support any custom ROMs and I’m not willing to risk a gsi build or similar to get lineage working. I think my current Motorola edge 40 neo will last me another 2 years maybe, but once it starts showing signs of death, I will be buying something either pre-installed with Linux or offers a straight forward enough path to flash Linux of some sort. I am happy with a clean experience with a solid web browser and no other apps. As another option, being able to install android apps would be good, but I don’t want that if it compromises the os.