What I don’t get is why it took them decades to figure this out. Why have they been giving us sugar substitutes without understanding what they have been doing to us? Why were these approved for use in the first place?
Copied from another posting of this article:
The headline (and the article for that matter) are very sensationalist and I don’t think they’ve presented this in a balanced way. They are discussing how sorbitol behaves in zebrafish with limited data presented on human biochemistry, and they discuss it in a vacuum without quantifying the amount of sorbitol it takes to cause a problem. Yes, any substance in excess can be harmful, but the amount of sorbitol in food compared to the amount of high fructose corn syrup makes it the substantially lesser evil. The artificial sweeteners are vastly more potent than actual sugar, so you don’t need very much of it to get the same amount of sweetness. High fructose corn syrup is used in massive amounts in food and is much worse for you on the scale that either substance would be consumed.
The scientific paper grift chain: get private funding from a company to publish a paper, use wild methodology, have the shit denounced and condemned by mainstream academia but not before every fucking news outlet in the world puts out a headline “BREAKING: SCIENTIFIC PAPER LINKS EATING SALAD TO BRAIN-EXPLODING DISEASE”
Never mind that to get this evidence they had to inject a marmot with enough salad dressing directly into its skull to make it explode thousand-island grey matter across its cage.
There’s a whole cycle of perverse incentives with University Press.
The underlying research is necessary and valuable but the marketing arm of universities blow everything out of proportion.
… In fish.
Do you think scientists start doing qualitative testing on humans first???
No, but I do expect people to assume this is based on humans which it isnt. If this research eventually gets there then we can see what it says, but for now it’s just another click bait article.
Comments like this are ignorant to evolution. Zebrafish are an extremely powerful model for drug development and toxicology.
You are obviously correct.
Nonetheless, the headline doesn’t even hint at the YEARS of research required before this becomes something people should worry about.
What? I’m saying most research translates to humans and therefore people should cut back on sorbitol immediately or risk liver damage. Especially since people have very poor diets and do not maintain healthy gut flora. Are you seriously taking the stance that we should ignore this study and consume sorbitol? You first.
Maybe
Half baked (well done, but incomplete) research has said:
-Eggs are dangerous to eat
-Saccharine causes bladder cancer
-Smoking is good for colds
-The way to lose weight is to eat a low fat high carb diet.
Maybe not
Part of science is recognizing how strong your data are and not generating hysteria after every research paper.
What REALLY sucks is that we can no longer rely on the CDC and NIH to make recommendations.
So you are free to cut sorbitol out of your diet and it may turn out to be a good choice. If that change makes you and others obviously healthier, I am sure this research will be repeated and expanded and soon we will all look back and remember having had your opinion.
Edited formatting for readability
…people used to think smoking was good for colds? Was it just menthols and the mint flavor?
I think it was nicotine withdrawal for the people not smoking.
To be fair I think Doctors testimonies were heavily considered until frighteningly recently.
Not at all, I’m just aware that this may not have any relevance to people, and right now it’s little more than click bait fodder.
Zebrafish are an extremely powerful model for drug development and toxicology.
Sure. But there’s also a reason we don’t do in silico molecular dynamics, test toxicology on zebrafish, and boom done drug is on the market. Even extremely close organisms, with LCAs much earlier than the zebrafish, can have wildly different reactions to potential drugs and dietary elements.
There are things you can feed a chimp but not a human.
And after they had depleted the zebrafish’s gut microbiota.
I’m not sure why people expected all these sugar substitutes to be harmless
The entire notion of sugar substitution in the first place should be such an insane concept to everyone but somehow we’ve instead created a diet soda and junk food entitlement
They have been used for decades without issue.
It takes decades to do the research or develop the issues
Genotoxicity of aspartame
https://pmc.ncbi.nlm.nih.gov/articles/PMC4235942/
Cancer risk of Erythritol
https://www.sciencedaily.com/releases/2025/07/250718035156.htm
https://www.health.harvard.edu/heart-health/sugar-substitutes-new-cardiovascular-concerns
Hope you dont use salt, that can cause cancer
Sugar isn’t harmless.
It is if you don’t eat too much
But aspartame will literally damage the DNA in your colon because it’s inherently genotoxic to our cells
The DNA damage comes from the formaldehyde that the body produces when metabolizing aspartame, but guess what? The body makes formaldehyde anyway, just from its natural metabolic processes. As long as you don’t consume too much it’s fine.
The problem is over-consumption, which is the basis of having a consumer economy. If everyone ate less the food industry would collapse. They need us to overeat and if we ever stopped they’d have to reconcile with the fact that they can’t just keep growing their profits infinitely. Plus, when we overeat, they can make even more money by treating the sicknesses it causes. Win/Win!
Don’t consume either. Artificial sweeteners are UPFs and sugar in all its forms have no place in the human diet.
Indeed, we should all be trying to reduce even sugar to 0
If there is a food Overton window it’s a solar system away from a normal diet
If you remove sugar in all its forms from your diet then you’d better forget about eating any plants whatsoever. Cellulose is sugar, carbs are sugar. Where do you think we get our energy from?
Amino acids and fat. Why do we need sugar? It’s not an essential nutrient.
Lipids (fat) also gets converted into glucose before your body can use it. If we’re cutting out sugar in all forms then that counts too.
That is also my understanding. We needn’t consume any exogenous sugars in any form, since the body is able to make all it needs.
If we’re cutting out sugar in all forms then that counts too.
That’s nothing near to what I said. To reiterate my statement, there is no requirement for sugar in the human diet.
I can tell you know a lot about biology.
Is your objection to substitutions? Because that’s a very arbitrary line. Why is it that we call sorbitol a sugar substitute instead of calling sugar a sorbitol substitute? Grind up some plums to make juice, remove the sorbitol, add some sucrose in its place. Doesn’t sound all that different.
Sorbitol-degrading Aeromonas bacterial strains convert the sugar alcohol into a harmless bacterial byproduct.
“However, if you don’t have the right bacteria, that’s when it becomes problematic. Because in those conditions, sorbitol doesn’t get degraded and as a result, it is passed on to the liver,” he said.
Pretty big caveat but the sensationalist headline is all people will see.
Phew! Thank God I’m not a zebra fish, otherwise I’d need to seriously reconsider my diet high on sorbitol.
Tbh I am betting that it’s gonna come out that they’ve known about the health risks all along, but they tried to ignore/cover it up for profit reasons.
Give up sugar. Try it, and tell me it isn’t addictive.
Give up all sweeteners, because keeping them just makes you crave more, making it much harder.
I gave up sugar, and most fruits except berries. It made staying at my ideal weight MUCH easier. I really don’t need to think about it, I weigh myself every few weeks, and I’m always at my ideal weight. Exercise is the other part of the equation, I think we need to do both.
Oh who fucking cares? Everything we eat and breath is poison now. There is no saving anyone anymore.
Excuse me but I’m a better cook than that. Delicious poison is on the menu
It’s sorbitol.
I’ve never even seen this in any food. Think I’ll be okay.
It’s typically used in items where you would only be consuming small amounts at once. Like sugar free gum and mints.
The article calls it “common”, but I’ve only seen it in a single brand of low-carb ice cream. I’ve actively sought low-carb options for over a decade. It’s even less common than xylitol.
According to this site, stone fruits like apricots, peaches, cherries, etc., dates, chewing gum, horseradish, jams, pears, apples, prunes, raisins, and many sugar-free processed foods have significant amounts in them.
But…isn’t sorbitol a laxative??
I learned that one the hard way with some delicious sorbitol candies as a teenager.
Yes. Its also a sweetener.
all the -tols are laxatives, you heard ethyrthiol, i think its one of the potent ones that cause laxative effects the most. i heard tons of people were getting cramps or diarrhea for people who sensitive. some people are mildly affected by it, and some has no effect.
I think its one of the potent ones that cause laxative
No, that’s maltitol
So, that includes Fuckitol®, too? That makes sense.
That explains the last 18 years or so.
The real mvp right here, fuck headlines like this
But if they just put it in the title, people won’t click and get bombarded with ads! Think of the big corporations!
The reporter/publisher also doesn’t get anything
I am ok with this not being my responsibility.
The article doesn’t read as very concerning. Too much of anything usually means bad. Under the right conditions anything can be bad. Figuring out what can be bad and when it can be bad can often take decades. Don’t stress too much on trying to optomize out anything that can do you harm in a diet. You’d have nothing left to eat and even the greatest collective of biologist getting together to make the greatest nutritional shake meal replacement would probably miss something that causes issues decades down the line or people drink too much and overdose
